Effectiveness and safety of azvudine in older adults with mild and moderate COVID-19: a retrospective observational study

The study titled “Effectiveness and safety of azvudine in older adults with mild and moderate COVID-19: a retrospective observational study” evaluated the use of azvudine, a nucleoside analog, in treating older adults with mild or moderate COVID-19. Here’s a detailed summary: Background of the Study: The COVID-19 pandemic has significantly impacted global health, with older adults particularly at risk due to their likelihood of having comorbidities. Despite the known benefits and safety of azvudine in treating COVID-19, there was limited data on its effectiveness and safety in older adult patients. This study aimed to fill this gap​​. Methodology: Conducted at…

Broad-spectrum antiviral activity of two structurally analogous CYP3A inhibitors against pathogenic human coronaviruses in vitro

The study titled “Broad-spectrum antiviral activity of two structurally analogous CYP3A inhibitors against pathogenic human coronaviruses in vitro” focuses on the antiviral properties of two drugs, cobicistat and ritonavir, against human coronaviruses, particularly SARS-CoV-2 and its variants. Here’s a detailed summary: Background: Coronaviruses like SARS-CoV, MERS-CoV, and SARS-CoV-2 pose a significant risk of outbreaks. The pandemic highlighted the need for effective antivirals. Cobicistat and ritonavir, both CYP3A inhibitors, have shown antiviral activity against early circulating SARS-CoV-2 strains. The study aims to compare their effects on various SARS-CoV-2 variants and other human coronaviruses​​​​. Antiviral Activity against SARS-CoV-2 Variants: The study analyzed…