One disease, many faces – typical and atypical presentations of SARS-CoV-2 infection-related COVID-19 disease

This study titled “One disease, many faces – typical and atypical presentations of SARS-CoV-2 infection-related COVID-19 disease” by Philips CA et al., published in the World Journal of Clinical Cases provides a comprehensive review focusing on the various clinical presentations of COVID-19, emphasizing the disease’s multisystem impact and the diverse symptoms beyond the commonly known respiratory manifestations. Abstract Summary: The review acknowledges that while COVID-19 is primarily known for respiratory symptoms, there is significant evidence of a wide range of clinical presentations. This review aims to provide an in-depth analysis of these varied presentations, which is crucial for frontline clinicians…

Aberrant olfactory network functional connectivity in people with olfactory dysfunction following COVID-19 infection

The study “Aberrant olfactory network functional connectivity in people with olfactory dysfunction following COVID-19 infection” focuses on the impact of COVID-19 on the brain’s olfactory networks. This exploratory observational study used multi-modal magnetic resonance imaging (MRI) techniques to assess changes in functional connectivity (FC), cerebral blood flow (CBF), and gray matter (GM) density in individuals with COVID-19-related anosmia (loss of smell). Key findings from the study include: In summary, the study sheds light on the neural alterations in individuals with long-term olfactory dysfunction following COVID-19 infection, offering a foundation for future research and potential therapeutic interventions. Read More: https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(23)00060-3/fulltext

SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming

The study titled “SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming” offers crucial insights into how SARS-CoV-2 infects nasal epithelium. Here’s a detailed summary: In summary, this study provides comprehensive insights into the mechanisms of SARS-CoV-2 infection, emphasizing the roles of motile cilia, microvilli, mucociliary transport, and kinase regulation in viral entry, replication, and spreading, with significant implications for understanding and targeting the virus. Read More: https://www.cell.com/cell/fulltext/S0092-8674(22)01505-7

Symptoms and risk factors for long COVID in non-hospitalized adults

The study, using a UK-based primary care database, investigated long COVID symptoms and risk factors in non-hospitalized adults. It involved 486,149 adults with confirmed SARS-CoV-2 infection and 1,944,580 matched adults without recorded SARS-CoV-2 infection. The study identified 62 symptoms significantly associated with SARS-CoV-2 infection after 12 weeks, with the most notable being anosmia, hair loss, sneezing, ejaculation difficulty, and reduced libido. Key findings of the study include: Overall, the study underscores the complexity and heterogeneity of long COVID, highlighting a broad spectrum of symptoms and the influence of various risk factors. This information is crucial for understanding the long-term effects…