Clinical and Electrocardiographic Correlates of Myocardial Dysfunction after COVID-19

A study published in the Journal of Medical Virology in 2023 by Kapusta et al. offers novel insights in to the predictors of myocardial dysfunction following COVID-19, particularly in nonhospitalized patients without previous cardiovascular disease.

Here’s a detailed summary:

  1. Background: The study acknowledges that COVID-19 significantly impacts the cardiovascular system, but there’s limited knowledge about the predictors of myocardial dysfunction after SARS-CoV-2 infection​​.
  2. Key Findings:
    • Myocardial Dysfunction Cases: The study diagnosed myocardial dysfunction in 29 patients, primarily characterized by contractility disorders. Out of these, seven had reduced left ventricular ejection fraction (LVEF), and reduced LVEF was also found in six out of 17 patients via echocardiography (ECHO) and all of them in magnetic resonance imaging (MRI)​​.
    • ECG Indicators: A statistically significant higher incidence of QRS fragmentation, arrhythmias (atrial fibrillation, supraventricular extrasystole, ventricular extrasystole), and atrial fibrillation were observed in patients with myocardial dysfunction after COVID-19. However, no serious arrhythmias or conduction disturbances were reported in patients with heart damage after COVID-19​​.
    • Independent Predictors: Multivariate analysis indicated QRS fragmentation and cardiac arrhythmias as independent predictors of myocardial dysfunction after COVID-19. The study also found a higher risk of myocardial dysfunction in men​​.
    • QRS Fragmentation (fQRS): Defined on the routine 12 lead ECG, QRS fragmentation is a marker of depolarization abnormalities. It’s associated with myocardial scarring and mortality in patients with ischemic heart disease and predicts arrhythmic events​​.
  3. Significance and Novelty: The results are significant as they identify novel predictors of myocardial injury in nonhospitalized COVID-19 convalescents without previous cardiovascular disease. The study suggests that ECG discrepancies, such as QRS fragmentation, ST depression, T-wave inversion, and ST-T changes, provide valuable diagnostic clues and are correlated with the severity of the disease​​.
  4. Implications: These findings emphasize the importance of electrocardiographic evaluation in COVID-19 patients, even in nonhospitalized cases, to detect potential myocardial dysfunction. It also highlights the need for further research on this subject to better understand and manage the cardiovascular implications of COVID-19.

In conclusion, this study sheds light on the cardiovascular effects of COVID-19, specifically myocardial dysfunction, and underscores the value of electrocardiographic analysis in its detection and management.

Read More: https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmv.29331

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