Coronavirus Disease-19 (COVID-19) Related Acute Stroke Causing Transient Global Amnesia

The study titled “Coronavirus Disease-19 (COVID-19) Related Acute Stroke Causing Transient Global Amnesia” by Ramnath Santosh Ramanathan MD and Ari Wachsman MD, focuses on the relationship between COVID-19 and transient global amnesia (TGA) caused by acute strokes.

Here is a summary of the key findings:

  1. Background on Transient Global Amnesia (TGA): TGA typically presents as acute, temporary amnesia, resolving within 24 hours. The study notes an increase in TGA cases during the COVID-19 pandemic.
  2. Case Studies: The research includes two case studies of patients who presented with TGA symptoms and were found to be COVID-19 positive. Both patients had a medical history of hypertension and experienced confusion and amnesia. Imaging tests revealed small acute strokes in the medial temporal lobes of their brains.
  3. Connection Between COVID-19 and TGA: The study suggests a possible link between COVID-19 and increased thrombotic vascular events like stroke, which could lead to TGA. COVID-19 has been associated with a hypercoagulable state due to systemic inflammation and cytokine storm, which might result in strokes.
  4. Findings and Hypothesis: In these cases, TGA appeared to be a direct result of acute strokes in the medial temporal lobe, possibly due to COVID-19-related thrombotic events. This contrasts with other reports that attributed TGA to the stress of the pandemic rather than to structural brain damage.
  5. Significance and Recommendations: The study emphasizes that TGA could be an initial manifestation of COVID-19 in some cases. It suggests the need for further reporting and investigation to understand the pathogenesis and characteristic neuroimaging findings in such patients.

This study is significant as it adds to the growing body of evidence on the neurological impacts of COVID-19, particularly regarding its potential to cause vascular events leading to conditions like TGA. It highlights the importance of considering COVID-19 as a possible underlying factor in cases of acute stroke and transient amnesia, especially during the pandemic.

Read More: https://www.sciencedirect.com/science/article/pii/S1052305721001415

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