Endocarditis caused by Aspergillus fumigatus in a patient 9 months after COVID-19 infection recovery: a case report and review of the literature

The study titled “Endocarditis caused by Aspergillus fumigatus in a patient 9 months after COVID-19 infection recovery: a case report and review of the literature” presents a rare case of post-COVID-19 Aspergillus endocarditis. This case is significant because it occurred in a patient with only mild immunosuppression, raising awareness about the potential complications following COVID-19.

Key Findings:

  • Case Overview: A 58-year-old Iranian woman developed Aspergillus fumigatus endocarditis 9 months after recovering from COVID-19. She had a history of rheumatoid arthritis but no prior cardiac disease.
  • Clinical Presentation: The patient experienced thromboembolisms, underwent mitral valve replacement surgery, and required multiple embolectomies.
  • Diagnosis and Treatment: The infection was confirmed through culture, histopathological evaluation, and PCR sequencing. Despite initial treatment with Amphotericin B, the pathogen was resistant, necessitating a switch to Voriconazole.
  • Outcome: The patient’s condition improved after the change in treatment and surgical interventions.

Discussion Points:

  • Fungal Endocarditis Post-COVID: The case underlines the risk of fungal endocarditis, particularly Aspergillus, in post-COVID-19 patients, even those with mild immunosuppression.
  • COVID-19 and Immune Dysregulation: The study discusses how COVID-19 can lead to immune dysregulation, increasing susceptibility to opportunistic infections like Aspergillus.
  • Importance of Early and Accurate Treatment: The report emphasizes the necessity for prompt, correct antifungal therapy and surgical intervention to improve patient outcomes.


  • Vigilance for Aspergillus Endocarditis: Clinicians should be aware of the possibility of Aspergillus endocarditis in post-COVID-19 patients, even without severe immunosuppression or cardiac history.
  • Need for Comprehensive Diagnostic Approach: A combination of culture, histopathology, and PCR is crucial for accurate diagnosis.
  • Early Intervention: Early initiation of appropriate antifungal therapy and surgical management is key to improving prognosis.

The study serves as a crucial reminder of the varied and potentially severe long-term complications of COVID-19, highlighting the need for continuous vigilance and a comprehensive approach to post-COVID-19 patient care.

Read More: https://jmedicalcasereports.biomedcentral.com/articles/10.1186/s13256-023-04252-x

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