Long COVID and Its Impact on Heart Rate Variability: A Detailed Study Analysis

A recent study explored the impact of Long COVID on heart rate variability (HRV) at rest and during deep-breathing maneuvers (M-RSA), providing valuable insights into the condition’s long-term effects on cardiac and autonomic function.

Key Findings:

  1. Reduced HRV in Long COVID Patients: The study observed a significant reduction in HRV measures in Long COVID patients compared to controls. This was evident both in the supine position and during the M-RSA. Indicators such as Mean_iRR, STD_iRR, STD_HR, SD1, SD2, and alpha2 showed significant reductions in Long COVID patients​​.
  2. Altered Autonomic Tone and Cardiovascular Risk: The study found that at rest, Long COVID patients presented altered time and non-linear indexes of HRV. This suggests higher heart rates, lower parasympathetic tone, decreased variability of RR intervals, and impaired fluctuation analysis with an increased risk of sudden death. During the M-RSA, although there was an increase in the time index of HRV, the response was significantly lower than in controls, reinforcing the findings of reduced parasympathetic tone and heart rate dynamics​​.
  3. Clinical Relevance and Limitations: The use of the Pro-Trainer 5 with POLAR software for assessing HRV in different postures and during M-RSA is a novel approach in this study. This tool, being cost-effective and practical, is of great clinical relevance in diagnosing autonomic dysfunction and cardiovascular risk in Long COVID patients. However, the study had some limitations, such as its single-center nature, small sample size, and lack of inclusion of asymptomatic COVID-19 patients. Additionally, there was no long-term follow-up to determine if HRV dysfunction persists over time​​.


The study concludes that patients with Long COVID exhibit abnormal autonomic tone, characterized by depressed HRV, suggesting lower parasympathetic tone and reduced complexity of HRV. These findings indicate a potential risk of sudden death and highlight the need for strategies to improve cardiac and autonomic responses in patients with Long COVID symptoms. Further investigation into pharmacological and non-pharmacological interventions to address these issues is warranted.

This study adds to the growing body of research on the long-term effects of COVID-19, specifically on cardiac and autonomic functions, underscoring the importance of ongoing monitoring and management of Long COVID symptoms.

Read More: https://www.nature.com/articles/s41598-023-50276-0

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