• Brainstem volume changes in myalgic encephalomyelitis/chronic fatigue syndrome and long COVID patients – “This study reports volumetric differences in the whole brainstem and four subregions in ME/CFS, long COVID, and HC. We showed that pons, SCP, and whole brainstem volumes were significantly larger in long COVID patients compared with HC. Similarly, pons and whole brainstem volumes were significantly larger in ME/CFS patients compared with HC. Interestingly, no brainstem subregion volumes were significantly different between ME/CFS and long COVID patients between ME/CFS and long COVID patients. To the authors’ knowledge this is the first investigation to demonstrate the overlap between ME/CFS and long COVID metrics using MRI. We also demonstrated that “pain” and “breathing difficulty” are strongly associated with brainstem volumes in ME/CFS and long COVID.”
  • Long COVID: major findings, mechanisms and recommendations – “Long COVID is a multisystemic illness encompassing ME/CFS, dysautonomia, impacts on multiple organ systems, and vascular and clotting abnormalities. It has already debilitated millions of individuals worldwide, and that number is continuing to grow. On the basis of more than 2 years of research on long COVID and decades of research on conditions such as ME/CFS, a significant proportion of individuals with long COVID may have lifelong disabilities if no action is taken. Diagnostic and treatment options are currently insufficient, and many clinical trials are urgently needed to rigorously test treatments that address hypothesized underlying biological mechanisms, including viral persistence, neuroinflammation, excessive blood clotting and autoimmunity.” 
  • Orthostatic Intolerance in Long-Haul COVID after SARS-CoV-2: A Case-Control Comparison with Post-EBV and Insidious-Onset Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients – “The complaints of long-haul COVID patients, the severity of the complaints, the orthostatic intolerance complaints in daily life, the orthostatic intolerance complaints during the tilt table test and the objective abnormalities of the orthostatic intolerance (the abnormal cerebral blood flow decrease and the abnormal cardiac index decrease) are very similar to those of the ME/CFS patients. This makes it very likely that long-haul COVID is the same in terms of disease as ME/CFS, where the trigger for its onset has been an infection with the SARS-CoV-2 virus. The treatment of long-haul COVID should therefore be similar to that of ME/CFS.”
  • Severe Fatigue and Persistent Symptoms at 3 Months Following Severe Acute Respiratory Syndrome Coronavirus 2 Infections During the Pre-Delta, Delta, and Omicron Time Periods: A Multicenter Prospective Cohort Study – “Prolonged symptoms following SARS-CoV-2 infection were more common among participants infected during pre-Delta than with Delta and Omicron; however, these differences were no longer significant after adjusting for vaccination status, suggesting a beneficial effect of vaccination on risk of long-term symptoms.”
  • The Occurrence of Hyperactivated Platelets and Fibrinaloid Microclots in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) – “Fibrinaloid microclots and associated coagulation issues are present in ME/CFS and point to a systemic vascular pathology and potential endothelial inflammation. Although the number of participants was low, these results pave the way for larger studies. Targeted therapies to address vascular and endothelial pathology might benefit relevant individuals, although further corroboration and expansion of the present findings are required before clinical commitment. Treating apparent vascular pathology has the potential to result in the amelioration of fatigue and other ME/CFS symptoms, as it did in a Long COVID/PASC population where symptom alleviation coincided with a decrease in fibrinaloid microclot load.”