Mid and long-term neurological and neuropsychiatric manifestations of post-COVID-19 syndrome: A meta-analysis

The study titled “Mid and long-term neurological and neuropsychiatric manifestations of post-COVID-19 syndrome: A meta-analysis” offers crucial insights into the long-term effects of COVID-19.

Here’s a detailed summary:

Background: The study addresses the prevalence of neurological and neuropsychiatric symptoms persisting or developing three months after the onset of COVID-19, contributing to the global healthcare burden. It aims to synthesize and quantify these symptoms via meta-analysis​​.

Objective and Methods: The study focused on evaluating the prevalence of neurological and neuropsychiatric symptoms three months post-acute COVID-19 infection. It analyzed 18 studies encompassing a total of 10,530 patients, comparing symptoms in hospitalized and non-hospitalized patients, with and without ICU admission, and at mid-term (3 to 6 months) and long-term (over 6 months) follow-ups​​.

Key Findings:

  • Fatigue was the most frequently reported symptom of neurological post-COVID-19 syndrome (37%), followed by brain fog (32%), sleep disturbances (31%), and memory issues (28%)​​.
  • Neuropsychiatric symptoms like anxiety and depression increased significantly in prevalence at long-term follow-up compared to mid-term​​.
  • Patients who were hospitalized during acute COVID-19 were less likely to develop symptoms like anosmia, anxiety, depression, dysgeusia, fatigue, headache, memory issues, myalgia, and sleep disturbances three months or more after COVID-19 onset compared to those who were not hospitalized​​.

Conclusion: The meta-analysis demonstrated that neurological and neuropsychiatric symptoms are common in post-COVID-19 syndrome, with roughly one-third of patients experiencing symptoms like fatigue and cognitive dysfunction three months after acute COVID-19. These symptoms tend to persist and become more common over time, indicating that post-COVID-19 syndrome is a significant long-term public health concern. The study highlights the need for increased awareness and research into interventional strategies to improve the quality of life and reduce the burden of post-COVID-19 syndrome​​.

Overall, this study provides valuable insights into the long-term neurological and neuropsychiatric impacts of COVID-19, underscoring the importance of long-term care and research for affected individuals.

Read More: https://www.sciencedirect.com/science/article/pii/S0022510X22000211

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