Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)

The study titled “Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)” provides critical insights into the impact of COVID-19 on T cell populations.

Here’s a summary:

  1. Background and Methods: The study focused on evaluating T cell counts and their functional state in COVID-19 patients. It retrospectively reviewed T cell counts and serum cytokine concentrations in 522 patients with laboratory-confirmed COVID-19 and 40 healthy controls. Additionally, it measured the expression of T cell exhaustion markers in 14 COVID-19 cases​​.
  2. Key Findings:
    • Reduced T Cell Counts: There was a dramatic reduction in the number of total T cells, including CD4+ and CD8+ T cells, in COVID-19 patients, especially those requiring Intensive Care Unit (ICU) care. Lower T cell counts were negatively correlated with patient survival​​.
    • Correlation with Cytokines: T cell numbers were negatively correlated with serum levels of IL-6, IL-10, and TNF-α. Patients in the disease resolution period showed reduced cytokine concentrations and restored T cell counts. This suggests that the decrease in T cells may result from high serum concentrations of these cytokines negatively regulating T cell survival or proliferation​​.
    • T Cell Exhaustion: COVID-19 patients, particularly those in ICU, showed higher levels of PD-1+CD8+ and CD4+ T cells, indicating T cell exhaustion. This exhaustion progressively increased in CD8+ T cells during the disease’s overtly symptomatic and ICU stages. Such exhaustion was associated with the expression of immune-inhibitory factors like PD-1 and Tim-3​​.
  3. Conclusions: The study concludes that T cell counts are significantly reduced in COVID-19 patients and that the surviving T cells appear functionally exhausted. This information is crucial for understanding the immune response in COVID-19 patients and may guide future treatments, particularly in managing severe cases.

These findings provide a deeper understanding of the immune system’s response to COVID-19 and highlight the importance of monitoring T cell levels and function for effective patient management.

Read More: https://www.frontiersin.org/articles/10.3389/fimmu.2020.00827/full

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