Risk of death following COVID-19 vaccination or positive SARS-CoV-2 test in young people in England

The study, titled “Risk of death following COVID-19 vaccination or positive SARS-CoV-2 test in young people in England” examines the impact of COVID-19 vaccination and positive SARS-CoV-2 tests on the risk of cardiac and all-cause mortality among young individuals aged 12 to 29 years. Utilizing a self-controlled case series design and national linked electronic health data, the study provides vital insights into the post-vaccination and post-infection mortality risks in this age group.

Here’s a detailed summary:

Overview of Findings:

  1. Post-Vaccination Mortality Risk: The study shows no significant increase in cardiac or all-cause mortality in the 12 weeks following COVID-19 vaccination compared to more than 12 weeks after any dose. However, it does note an increase in cardiac death in women after a first dose of non-mRNA vaccines. Specifically, the study observes no significant increases in the incidence of any mortality outcome for all vaccine doses combined across each individual week or all twelve weeks combined. A significant decrease in the incidence of all-cause registered death was found in the first two weeks post-vaccination​​.
  2. Post-Infection Mortality Risk: A positive SARS-CoV-2 test is associated with increased cardiac and all-cause mortality among both vaccinated and unvaccinated individuals at the time of testing. Specifically, unvaccinated individuals showed an increase in the incidence of cardiac death and higher incidences of all-cause mortality for both registered and hospital deaths, particularly pronounced in the first week post-infection​​.

Conclusions and Implications: The study contributes important knowledge about the risk of death following COVID-19 vaccination and a positive SARS-CoV-2 test in young individuals. The findings are particularly relevant for public health policies and individuals making informed decisions about vaccination and COVID-19 risk management. The significant increase in mortality post-infection underscores the ongoing risk posed by the virus, while the largely reassuring post-vaccination data supports the continued use of vaccines, particularly given the heightened risk associated with infection. However, the noted increase in cardiac deaths in women following a first dose of non-mRNA vaccines warrants further investigation and consideration in vaccine administration strategies​​.

In summary, this study highlights the nuanced and differential impacts of COVID-19 vaccination and infection on young individuals’ mortality risks, offering valuable insights for healthcare providers, policymakers, and the public.

Read More: https://www.nature.com/articles/s41591-022-02051-3

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