SARS-CoV-2 infection and persistence throughout the human body and brain

The study titled “SARS-CoV-2 Infection and Persistence Throughout the Human Body and Brain,” provides significant insights into the behavior and impact of the COVID-19 virus on the human body.

Here are the key findings:

  1. Widespread Distribution of SARS-CoV-2: The study, which involved complete autopsies on 44 COVID-19 patients, revealed that SARS-CoV-2 is widely distributed across the human body, including the brain. This distribution was noted even in patients who had died from COVID-19 with asymptomatic to mild symptoms.
  2. Virus Replication in Multiple Tissues: The researchers found that virus replication occurs in various pulmonary and extrapulmonary tissues early in the infection.
  3. Persistence of the Virus: Importantly, the study detected persistent SARS-CoV-2 RNA in multiple anatomical sites, including different regions of the brain, for up to 230 days following the onset of symptoms.
  4. Lack of Inflammation in Extrapulmonary Organs: Despite the extensive distribution of the virus, there was a notable lack of inflammation or direct viral cytopathology outside of the lungs.
  5. Systemic Infection and Longevity of the Virus: The findings conclusively show that SARS-CoV-2 causes a systemic infection that can persist in the body for several months.
  6. Implications for Long COVID (PASC): The study adds to the understanding of Post-Acute Sequelae of SARS-CoV-2 (PASC), commonly known as Long COVID, by highlighting the ability of the virus to affect multiple organs and persist over a prolonged period.

In summary, the research provides crucial information on how SARS-CoV-2 can spread and remain in the human body, contributing to our understanding of both acute COVID-19 and Long COVID​​.

Read More: https://www.researchsquare.com/article/rs-1139035/v1

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