Cardiac SARS-CoV-2 infection is associated with pro-inflammatory transcriptomic alterations within the heart

The study titled “Cardiac SARS-CoV-2 infection is associated with pro-inflammatory transcriptomic alterations within the heart” explores the cardiac involvement in COVID-19 and its specific cellular effects. Conducted on 95 autopsy cases with confirmed SARS-CoV-2 infection, it used in situ hybridization, immunohistochemistry, and RNA-sequencing to analyze heart tissue, focusing on virus load and cardiac implications of COVID-19​​. Key Findings: Conclusion: The study underscores the importance of understanding cardiac implications in COVID-19. The cardiac tissue of deceased COVID-19 patients showed significant transcriptomic alterations, especially in endothelial cells, without traditional signs of increased immune cell infiltration. The findings suggest that the cardiac implications…