Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses

The review titled “Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses” provides a comprehensive analysis of the immune response to coronaviruses, particularly focusing on how the immune system’s reaction can contribute to the severity of diseases like COVID-19. Here is a detailed summary: Abstract Interferon Responses Viral Protein Antagonism Inflammatory Response Complement System Adaptive Immunity T Cell-Mediated Pathogenesis Humoral Immunity Conclusion This review highlights the complex interplay between the immune system and coronaviruses, emphasizing the balance between effective viral clearance and the prevention of immune-mediated pathology. It underscores the need for a deeper understanding of these interactions to…

The immunology and immunopathology of COVID-19

The study titled “The immunology and immunopathology of COVID-19” provides a comprehensive review of nearly two years of research into the immune response to SARS-CoV-2 infections, the drivers of severe and fatal COVID-19, and factors contributing to Long Covid, or post-acute sequelae of SARS-CoV-2 (PASC). Here’s a detailed summary: In conclusion, this study provides valuable insights into the complex interplay of the immune system with SARS-CoV-2, contributing to our understanding of both acute and long-term COVID-19 complications. It highlights the need for ongoing research to further elucidate these mechanisms and develop effective treatments for both acute and chronic manifestations of…