Multiple layers of innate immune response antagonism of SARS-CoV-2

The study, titled “Multiple layers of innate immune response antagonism of SARS-CoV-2,” presents an extensive analysis of the role of various SARS-CoV-2 proteins in modulating the host’s innate immune response. The researchers focused on twelve specific viral proteins, including NSP1, NSP2, NSP3, NSP6, NSP12, NSP13, NSP14, NSP15, NSP16, ORF3a, ORF6, and ORF8. They utilized a SARS-CoV-2 bacterial artificial chromosome combined with en passant mutagenesis to generate a series of infectious recombinant SARS-CoV-2 viruses, each carrying mutations in one of these proteins. Key findings of the study include: In summary, this research provides valuable insights into the complex interplay between SARS-CoV-2…