Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses

The review titled “Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses” provides a comprehensive analysis of the immune response to coronaviruses, particularly focusing on how the immune system’s reaction can contribute to the severity of diseases like COVID-19. Here is a detailed summary: Abstract Interferon Responses Viral Protein Antagonism Inflammatory Response Complement System Adaptive Immunity T Cell-Mediated Pathogenesis Humoral Immunity Conclusion This review highlights the complex interplay between the immune system and coronaviruses, emphasizing the balance between effective viral clearance and the prevention of immune-mediated pathology. It underscores the need for a deeper understanding of these interactions to…

Unraveling DPP4 Receptor Interactions with SARS-CoV-2 Variants and MERS-CoV: Insights into Pulmonary Disorders via Immunoinformatics and Molecular Dynamics

The study titled “Unraveling DPP4 Receptor Interactions with SARS-CoV-2 Variants and MERS-CoV: Insights into Pulmonary Disorders via Immunoinformatics and Molecular Dynamics” provides significant insights into the interactions between the SARS-CoV-2 spike protein, its variants, and the DPP4 receptor. Here’s a detailed summary: Background and Objectives: Methodology: Key Findings: Hydrogen Bonds Analysis: Interface Analysis: In conclusion, this study offers critical insights into how SARS-CoV-2 variants, particularly the Delta variant, interact with the DPP4 receptor. These interactions may have significant implications for the severity of COVID-19, especially in patients with comorbidities, highlighting the importance of DPP4 as a potential therapeutic target in…