Muscle abnormalities worsen after post-exertional malaise in long COVID

The study “Muscle abnormalities worsen after post-exertional malaise in long COVID” provides crucial insights into the pathophysiology of long COVID, particularly focusing on post-exertional malaise (PEM) and its effects on skeletal muscle. Here’s a detailed summary: Background: Long COVID, characterized by symptoms persisting for months after acute SARS-CoV-2 infection, commonly includes limited exercise tolerance and PEM. This study aimed to understand the underlying biology of these symptoms, especially the role of skeletal muscle structure and metabolic function​​. Methodology: The study involved 25 long COVID patients and 21 control participants who had recovered from a mild SARS-CoV-2 infection. Participants underwent cardiopulmonary…