Characterization of SARS-CoV-2 Evasion: Interferon Pathway and Therapeutic Options

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the cause of the ongoing COVID-19 pandemic. A defining feature of SARS-CoV-2 is its significant capacity to circumvent the human body’s innate immune response, particularly the early interferon (IFN) response. This evasion contributes to the disease’s pathogenicity and, in some cases, leads to severe and critical health conditions. The study underscores the importance of understanding the interplay between viral factors and host innate immunity to manage the disease effectively, especially considering the continuous emergence of new SARS-CoV-2 variants which challenge the efficacy of existing vaccines. Mechanisms of Immune Evasion by SARS-CoV-2: Therapeutic Options:…