Whole-body PET imaging reveals tissue-based immune activation and SARS-CoV-2 persistence in the post-acute phase of COVID-19

The study titled “Whole-body PET imaging reveals tissue-based immune activation and SARS-CoV-2 persistence in the post-acute phase of COVID-19” investigated the underlying mechanisms of Long COVID and post-acute medical issues following SARS-CoV-2 infection. Using whole-body positron emission tomography (PET) imaging on 24 participants, it employed a novel radiopharmaceutical agent, [18F]F-AraG, to quantitatively visualize activated T lymphocytes in various anatomical regions. Key Findings: Methodology: Limitations: Conclusion: The study provides evidence for ongoing immune responses in tissues, potentially contributing to inflammation observed in peripheral blood. It suggests that SARS-CoV-2 infection could lead to a new immunologic steady state, contributing to Long COVID…