Whole-body PET imaging reveals tissue-based immune activation and SARS-CoV-2 persistence in the post-acute phase of COVID-19

The study titled “Whole-body PET imaging reveals tissue-based immune activation and SARS-CoV-2 persistence in the post-acute phase of COVID-19” investigated the underlying mechanisms of Long COVID and post-acute medical issues following SARS-CoV-2 infection. Using whole-body positron emission tomography (PET) imaging on 24 participants, it employed a novel radiopharmaceutical agent, [18F]F-AraG, to quantitatively visualize activated T lymphocytes in various anatomical regions. Key Findings: Methodology: Limitations: Conclusion: The study provides evidence for ongoing immune responses in tissues, potentially contributing to inflammation observed in peripheral blood. It suggests that SARS-CoV-2 infection could lead to a new immunologic steady state, contributing to Long COVID…

SARS-CoV-2 viral persistence in lung alveolar macrophages is controlled by IFN-γ and NK cells

This study, titled “SARS-CoV-2 Viral Persistence in Lung Alveolar Macrophages is Controlled by IFN-γ and NK Cells,” published in Nature Immunology, provides significant insights into the persistence of SARS-CoV-2 in the body and the mechanisms regulating it. The key findings of the study are: The study underscores the complex interplay between immune cells and the SARS-CoV-2 virus, highlighting the persistence of the virus in lung macrophages and its implications for long-term immune response and inflammation. Read More: https://www.nature.com/articles/s41590-023-01661-4