SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS and uninfected controls

The study “SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS and uninfected controls” investigates T cell responses to SARS-CoV-2, including in individuals who recovered from COVID-19, those who recovered from SARS (caused by SARS-CoV), and unexposed donors. Here’s a detailed summary: In summary, this study provides significant insights into T cell immunity related to SARS-CoV-2, highlighting the presence of specific T cell responses in individuals recovered from COVID-19 and SARS, and even in unexposed individuals. It underscores the complexity and potential durability of T cell-mediated immunity in response to coronavirus infections, including COVID-19. This research contributes to the…

Long COVID manifests with T cell dysregulation, inflammation, and an uncoordinated adaptive immune response to SARS-CoV-2

The study titled “Long COVID manifests with T cell dysregulation, inflammation, and an uncoordinated adaptive immune response to SARS-CoV-2” by Kailin Yin and colleagues, aimed to understand the underlying mechanisms of Long COVID (LC)​​. Here’s a detailed summary: Study Overview Key Findings Study Limitations Conclusion The study underscores that LC is associated with an uncoordinated response between the humoral and cellular arms of adaptive immunity, as well as global immune dysregulation. This comprehensive analysis provides critical insights into the complex nature of LC and its underlying mechanisms. Read More: https://www.biorxiv.org/content/10.1101/2023.02.09.527892v2.full