COVID-19 and influenza infections mediate distinct pulmonary cellular and transcriptomic changes

The study “COVID-19 and influenza infections mediate distinct pulmonary cellular and transcriptomic changes” examines the differences in lung tissue response between SARS-CoV-2 and influenza (H1N1) infections in K18-human ACE2 transgenic mice. Key findings include: SARS-CoV-2 Infection Leads to Persistent Lung Abnormalities: Sub-lethally infected K18-human ACE2 mice showed patchy pneumonia, histiocytic inflammation, and collagen deposition at 21 and 45 days post-infection (DPI). In contrast to influenza, SARS-CoV-2-infected mice had reduced interferon-gamma/alpha responses and failed to induce keratin 5 (Krt5), a marker of nascent pulmonary progenitor cells. This suggests SARS-CoV-2 infection does not induce the proliferation of nascent Krt5+ cells in consolidated…