Lys417 acts as a molecular switch that regulates the conformation of SARS-CoV-2 spike protein

The study “Lys417 acts as a molecular switch that regulates the conformation of SARS-CoV-2 spike protein” delves into the critical role of the SARS-CoV-2 spike protein in virus transmission and immune system interaction. This protein can switch between an ‘open’ and ‘closed’ conformation, crucial for the virus’s entry into host cells and immune response induction. The study focuses on the residue Lys417 in the receptor-binding domain (RBD) of the spike protein, which is key in stabilizing its closed conformation and also directly interacts with the ACE2 receptor. Here are the main findings and implications of the study: In summary, the…