Unveiling the Connection Between COVID-19 and New-Onset Alzheimer’s Disease

A groundbreaking study published in the Journal of Alzheimer’s Disease has shed light on the potential link between COVID-19 and the increased risk of developing Alzheimer’s disease.

Here’s a detailed look at the findings:

Overview of the Study

  • Title: “Association of COVID-19 with New-Onset Alzheimer’s Disease”
  • Methodology: A retrospective cohort study involving over 6 million older adults (age ≥65 years) who had medical encounters between February 2020 and May 2021.

Key Findings

  • Increased Risk of Alzheimer’s Disease: The study found a significant association between COVID-19 and a heightened risk of developing Alzheimer’s disease. Specifically, individuals who had COVID-19 showed a 1.69 times higher risk (95% CI: 1.53–1.72) of being diagnosed with Alzheimer’s within 360 days post their initial COVID-19 diagnosis.
  • Particularly Vulnerable Groups: The risk was notably higher in specific demographics, especially in people aged ≥85 years and in women. In these groups, the hazard ratios were even more pronounced: 1.89 (95% CI: 1.73–2.07) for those aged ≥85 and 1.82 (95% CI: 1.69–1.97) for women.
  • Study Population Details: The study included a COVID-19 cohort of 410,748 individuals and a non-COVID-19 cohort of 5,834,534 individuals. The COVID-19 cohort had a higher prevalence of people from Hispanic and Black communities, along with more adverse socioeconomic factors and comorbidities.

Discussion and Implications

  • Understanding Long-term Impacts: This study calls for further research to understand the underlying mechanisms behind this association. It highlights the need for continuous surveillance of the long-term impacts of COVID-19, particularly concerning Alzheimer’s disease.
  • Study Limitations: The researchers acknowledge potential biases due to the observational and retrospective nature of the study. They also note the possibility of inaccuracies in Alzheimer’s disease diagnosis but believe this does not significantly affect the relative risk analyses.
  • Future Research Directions: The team suggests the need for validation from other data sources, longer-term follow-up studies, and investigations into the mechanisms involved. They also propose to examine the association between COVID-19 and other types of dementia.


This study presents compelling evidence linking COVID-19 with an increased risk of developing Alzheimer’s disease, particularly among older adults. As the world continues to grapple with the long-term effects of the COVID-19 pandemic, these findings underscore the importance of monitoring and addressing the cognitive health impacts in COVID-19 survivors.

Read More: https://eswi.org/cnt/article/association-covid-19-new-onset-alzheimers-disease-364

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